Playing with dexmedetomidine pharmacokinetics!
نویسندگان
چکیده
منابع مشابه
Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine
Dexmedetomidine is an α2-adrenoceptor agonist with sedative, anxiolytic, sympatholytic, and analgesic-sparing effects, and minimal depression of respiratory function. It is potent and highly selective for α2-receptors with an α2:α1 ratio of 1620:1. Hemodynamic effects, which include transient hypertension, bradycardia, and hypotension, result from the drug's peripheral vasoconstrictive and symp...
متن کاملPopulation Pharmacokinetics of Dexmedetomidine in Critically Ill Patients
BACKGROUND AND OBJECTIVES Although the pharmacokinetics of dexmedetomidine in healthy volunteers have been studied, there are limited data about the pharmacokinetics of long-term administration of dexmedetomidine in critically ill patients. METHODS This population pharmacokinetic analysis was performed to quantify the pharmacokinetics of dexmedetomidine in critically ill patients following in...
متن کاملPharmacokinetics of dexmedetomidine combined with therapeutic hypothermia in a piglet asphyxia model
BACKGROUND The highly selective α2 -adrenoreceptor agonist, dexmedetomidine, exerts neuroprotective, analgesic, anti-inflammatory and sympatholytic properties that may be beneficial for perinatal asphyxia. The optimal safe dose for pre-clinical newborn neuroprotection studies is unknown. METHODS Following cerebral hypoxia-ischaemia, dexmedetomidine was administered to nine newborn piglets in ...
متن کاملPlaying with Maude
This paper is an introduction to rule-based programming in Maude. We illustrate in particular the use of operator attributes to structure the state of a system, and the difference between equations and rules. We use well-known mathematical games and puzzles for our examples illustrating the expressive power of Maude.
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2020
ISSN: 0007-0912
DOI: 10.1016/j.bja.2019.11.019